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North West Cancer Research Fund Institute

Cancer & Stem Cell Genome Dynamics Group

Ramsay McFarlane

Name:

Dr. Ramsay McFarlane

Position:

Cancer & Stem Cell Genome Dynamics Group

Email:

Location:

Brambell

Phone:

+44 (0)1248 382360

Other Contacts

Tel:  +44 (0)1248 382369 (lab.)

Fax: +44 (0)1248 370731

Group members:

Centromere / Recombination Programme

  • Alessa Jaendling (Postdoctoral Research Associate)
  • Faisal Alzahran (Ph.D. student)

Cancer Oncogenes / Markers Programme

  • Julia Feichtinger (Ph.D student)
  • Ibrahim Aldeailej (Ph.D. student)
  • Becky Knight (Ph.D. student)
  • Naif Alsiwiehri (Ph.D. student)
  • Miklid Almutairi (Ph.D. student)
  • Ahmed Almatrafi (Ph.D. student)

Meiotic Chromosome Dynamcis Programme

  • Natalia Gomez-Escobar (Postdoctoral Staff Scientist)
  • Heledd Dafydd (Ph.D. Student)

Stem Cell Genome Dynamics Programme (co-leader with Dr. Wakeman)

  • Khalid Al-Zeer (Ph.D. Student)
  • Rafat Al-Hadithi (Ph.D. student)

Translin / TRAX Programme

  • Nasser Almobadel (Ph.D. Student)
  • Zafer Al-Shehri (Ph.D. Student)

 

Research Overview

Currently being updated.

 

Selected Publications

Centromere / Recombiantion Programme

McFarlane, R.J., Humphrey, T.C. (2010) A role for recombination in centromere function. Trends Genet. 26, 209-213.

McFarlane, R.J., Mian, S., Dalgaard, J.Z. (2010) The many facets of the Tim-Tipin protein families' roles in chromosome biology. Cell Cycle 9, 700-705.

Pryce, D.W., Ramayah, S., Jaendling, A., McFarlane, R.J. (2009) Recombination at DNA replication fork barriers is not universal and is differentially regulated by Swi1. Proc. Natl. Acad. Sci. USA 106, 4770-4775.

McFarlane, R.J., Whitehall, S.K. (2009) tRNA genes in eukaryotic genome organisation and reorganization. Cell Cycle 8, 3102-3106.

Smirnova, J.B., McFarlane, R.J. (2002) The unique centromeric chromatin structure of Schizosaccharomyces pombe is maintained during meiosis. J. Biol. Chem. 277, 19817-19822.

Jessen, J.R., Meng, A., McFarlane, R.J., Paw, B.H., Zon, L.I., Smith G.R., Lin, S. (1998) Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis. Proc. Natl. Acad. Sci. USA. 95, 5121-5126.

 

Cancer Oncogenes / Markers Programme

Publications pending

Meiotic Chromosome Dynamcis Programme

Spirek, M., Estreicher, A., Csaszar, E., Wells, J., McFarlane, R.J., Watts, F.Z., Loidl, J. (2010) SUMOylation is required for normal development of linear elements and wild-type meiotic recombiantion in Schizosaccharomyce pombe Chromosoma 119, 59-72.

Pryce, D.W., McFarlane, R.J. (2009) The meiotic recombination hotspots of Schizosaccharomyces pombe. Genome Dyn. 5, 1-13.

Wells, J.L., Pryce, D.W., Estreicher, A., Loidl, J., McFarlane, R.J. (2006) Linear element-independent meiotic recombiantion in Schizosaccharomyces pombe. Genetics 174, 1105-1114.

Wells, J.L., Pryce, D.W., McFarlane, R.J. (2006) Homologous chromosome pairing in Schizosaccharomyces pombe. Yeast 23, 977-989.

Pryce, D.W., Lorenz, A., Smirnova, J.B., Loidl, J., McFarlane, R.J. (2005) Differential activation of M26-containing meiotic recombination hot spots in Schizosaccharomyces pombe. Genetics 170, 95-106.

Lorenz, A., Wells, J.L., Pryce, D.W., Novatchkova, M., Eisenhaber, F., McFarlane, R.J., Loidl, J. (2004) S. pombe meiotic linear elements contain proteins related to synaptonemal complex components. J. Cell Sci. 117, 3343-3351.

Stem Cell Genome Dynamics Programme (co-leader with Dr. Wakeman)

Battersby, A., Jones, R.D., Lilley, K.S., McFarlane, R.J., Braig, H.R., Allen, N.D., Wakeman, J.A. (2007) Comparative proteomic analysis reveals differential expression of Hsp25 following the directed differentiation of mouse embryonic stem cells. Biochim Biophys Acta. Mol. Cell Res. 1773,147-156.

 

Translin / TRAX Programme

Jaendlin, A., McFarlane, R.J. (2010) Biological roles of translin and translin-associated factor X: RNA metabolism comes to the fore. Biochem J. 429, 225-234.

Jaendling, A., Ramayah, S., Pryce, D.W., McFarlane, R.J. (2008) Functional characterisation of the Schizosaccharomyces pombe homologue of the leukaemia-associated translocation breakpoint binding protein translin and its binding partner, TRAX. Biochim Biophys Acta. Mol. Cell Res. 1783, 203-213.

 

 

 

Current Support

  • KESS
  • Government of the Kingdom of Saudi Arabia
  • WORD / MRC
  • NHS
  • North West Cancer Research Fund (NWCRF)